New hematology study results reported from University of Rochester.

According to a study from the United States, "Active gene promoters are associated with covalent histone modifications, such as hyperacetylation, which can modulate chromatin structure and stabilize binding of transcription factors that recognize these modifications. At the beta-globin locus and several other loci, however, histone hyperacetylation extends beyond the promoter, over tens of kilobases; we term such patterns of histone modifications ''hyperacetylated domains.'' Little is known of either the mechanism by which these domains form or their function."

"Here, we show that domain formation within the murine beta-globin locus occurs before either high-level gene …